statMed.org is designed to help students of medicine to learn about differential diagnosis.
It is NOT a clinical decision support tool and should NOT be used to guide decisions about clinical practice.
The website should not be used by people who are not studying medicine. If you are not studying medicine please leave the website. statMed.org is for medical educational purposes only and it is not intended to constitute professional medical advice, diagnosis or treatment.
It is NOT a symptom checker.
If you are concerned about a medical problem you should immediately seek medical assistance from a doctor.
statMed.org and it's affiliates, officers and employees shall not be held liable in anyway responsible for any direct or indirect consquences resulting from the use of the website.
Please enter at least one feature (symptom, sign or investigation result) before performing the calculation.
For example, if chest pain and low oxygen saturations were present, but haemoptysis was absent, the features section should look as follows:
To add a feature that is present, start typing and then click the green arrow.
To add the absence of a feature (i.e. a 'negative' finding), start typing then click the red cross.
If you want to remove a feature from the list simply click the grey cross in the box to the right of the feature.
Tranexamic acid is an antifibrinolytic that is used in conditions where excessive bleeding is not desirable, e.g. menorrhagia and trauma.
Mechanism of action
Tranexamic acid is a synthetic derivative of lysine. Its primary mode of action is as an antifibrinolytic that reversibly binds to lysine receptor sites on plasminogen or plasmin. This prevents plasmin from binding to and degrading fibrin.
Tranexamic acid is most commonly prescribed to help treat menorrhagia.
The role of tranexamic acid in trauma was investigated in the CRASH 2 trial and has been shown to be of benefit in bleeding trauma when administered in the first 3 hours.
There is also ongoing research looking at the role of tranexamic acid in traumatic brain injury.