statMed.org is designed to help students of medicine to learn about differential diagnosis.
It is NOT a clinical decision support tool and should NOT be used to guide decisions about clinical practice.
The website should not be used by people who are not studying medicine. If you are not studying medicine please leave the website. statMed.org is for medical educational purposes only and it is not intended to constitute professional medical advice, diagnosis or treatment.
It is NOT a symptom checker.
If you are concerned about a medical problem you should immediately seek medical assistance from a doctor.
statMed.org and it's affiliates, officers and employees shall not be held liable in anyway responsible for any direct or indirect consquences resulting from the use of the website.
Please enter at least one feature (symptom, sign or investigation result) before performing the calculation.
For example, if chest pain and low oxygen saturations were present, but haemoptysis was absent, the features section should look as follows:
To add a feature that is present, start typing and then click the green arrow.
To add the absence of a feature (i.e. a 'negative' finding), start typing then click the red cross.
If you want to remove a feature from the list simply click the grey cross in the box to the right of the feature.
Sulfonylureas are oral hypoglycaemic drugs used in the management of type 2 diabetes mellitus. They work by increasing pancreatic insulin secretion and hence are only effective if functional B-cells are present.
Mechanism of action
They work by increasing pancreatic insulin secretion and hence are only effective if functional B-cells are present. On a molecular level they bind to an ATP-dependent K+(KATP) channel on the cell membrane of pancreatic beta cells.
Hypoglycaemic episodes (more common with long-acting preparations such as chlorpropamide)
Rarer adverse effects
Hyponatraemia secondary to syndrome of inappropriate ADH secretion
Bone marrow suppression
Hepatotoxicity (typically cholestatic)
Sulfonylureas should be avoided in breastfeeding and pregnancy.