Somatostatin analogues





Introduction

Overview
  • Long-acting analogue of somatostatin
  • Somatostatin is released from D cells of pancreas and inhibits the release of growth hormone, glucagon and insulin

Indications

Uses
  • Acute treatment of variceal haemorrhage: however, terlipressin is now generally preferred
  • Acromegaly
  • Carcinoid syndrome
  • Prevent complications following pancreatic surgery
  • VIPomas
  • Refractory diarrhoea

Adverse effects

  • Gallstones (secondary to biliary stasis)