Selective estrogen receptor modulator


Tamoxifen is a Selective oEstrogen Receptor Modulator (SERM) which acts as an oestrogen receptor antagonist and partial agonist. It is used in the management of oestrogen receptor positive breast cancer

Adverse effects

  • menstrual disturbance: vaginal bleeding, amenorrhoea
  • hot flushes - 3% of patients stop taking tamoxifen due to climateric side-effects
  • venous thromboembolism
  • endometrial cancer