Introduction
Overview
Non-selective monoamine oxidase inhibitors
- Serotonin and noradrenaline are metabolised by monoamine oxidase in the presynaptic cell
Non-selective monoamine oxidase inhibitors
- E.g. tranylcypromine, phenelzine
- Used in the treatment of atypical depression (e.g. hyperphagia) and other psychiatric disorder
- Not used frequently due to side-effects
Adverse effects
Adverse effects of non-selective monoamine oxidase inhibitors
- Hypertensive reactions with tyramine containing foods e.g. cheese, pickled herring, Bovril, Oxo, Marmite, broad beans
- Anticholinergic effects