Monoamine oxidase inhibitors


  • Serotonin and noradrenaline are metabolised by monoamine oxidase in the presynaptic cell

Non-selective monoamine oxidase inhibitors
  • E.g. tranylcypromine, phenelzine
  • Used in the treatment of atypical depression (e.g. hyperphagia) and other psychiatric disorder
  • Not used frequently due to side-effects

Adverse effects

Adverse effects of non-selective monoamine oxidase inhibitors
  • Hypertensive reactions with tyramine containing foods e.g. cheese, pickled herring, Bovril, Oxo, Marmite, broad beans
  • Anticholinergic effects