Metoclopramide is a D2 receptor antagonist mainly used in the management of nausea.


The main use is in the management of nausea and vomiting. Other uses include:
  • Gastro-oesophageal reflux disease
  • Prokinetic action is useful in gastroparesis secondary to diabetic neuropathy
  • Often combined with analgesics for the treatment of migraine (migraine attacks result in gastroparesis, slowing the absorption of analgesics)

Adverse effects

  • Extrapyramidal effects: oculogyric crisis. This is particularly a problem in children and young adults
  • Hyperprolactinaemia
  • Tardive dyskinesia
  • Parkinsonism


Metoclopramide should be avoided in bowel obstruction, but may be helpful in paralytic ileus.