Membranoproliferative glomerulonephritis


Type 1
  • Accounts for 90% of cases
  • Subendothelial immune deposits of electron dense material resulting in a 'tram-track' appearance
  • Cause: cryoglobulinaemia, hepatitis C

Type 2 - 'dense deposit disease'
  • Causes: partial lipodystrophy (patients classically have a loss of subcutaneous tissue from their face), factor H deficiency
  • Reduced serum complement
  • C3b nephritic factor (an antibody against C3bBb) found in 70%

Type 3
  • Causes: hepatitis B and C

Clinical features

May present as nephrotic syndrome, haematuria or proteinuria


  • Steroids may be effective