Meglitinides are infrequently used in the management of type 2 diabetes mellitus. They are sometimes useful in patients who have erratic lifestyles.

Mechanism of action

  • Increase pancreatic insulin secretion
  • Like sulfonylureas they bind to an ATP-dependent K+(KATP) channel on the cell membrane of pancreatic beta cells

Adverse effects

  • Weight gain
  • Hypoglycaemia (less so than sulfonylureas)