Introduction

Kartagener's syndrome (also known as primary ciliary dyskinesia) was first described in 1933. It is characterised by dextrocardia and bronchiectasis.

Pathophysiology

Pathogenesis
  • Dynein arm defect results in immotile cilia

Clinical features

  • Dextrocardia or complete situs inversus
  • Bronchiectasis
  • Recurrent sinusitis
  • Subfertility (secondary to diminished sperm motility and defective ciliary action in the fallopian tubes)