- Incubation phase
- This is the time period between coming into contact with the virus and developing symptoms.
- Approximately 28 days (range 15 to 50 days).
- Prodromal phase
- This refers to period where early symptoms develop before onset of fully-developed acute illness.
- Typically lasts 3 to 10 days.
- Symptoms include flu-like illness, gastrointestinal symptoms (such as appetite loss, right upper abdominal pain, nausea, vomiting and diarrhoea) and low-grade temperatures up to 39oC.
- Usually no specific signs on examination.
- Icteric phase
- This refers to period of established infection.
- Typically lasts 1 to 3 weeks, but can last up to 12 weeks.
- Symptoms include jaundice, pale stools and dark urine, pruritis (40% of those with jaundice), fatigue, anorexia, vomiting.
- There may be hepatomegaly (85%), splenomegaly (15%) and hepatic tenderness on examination.
- Convalescent phase
- This refers to period of recovery after acute illness.
- May last up to 6 months.
- Features include muscle weakness, malaise, anorexia and hepatic tenderness.
- Hepatitis serology
- First line is the PCR test for hepatitis A RNA.
- If this is not available, hepatitis A virus immunoglobulin M (HAV-IgM) and hepatitis A virus immunoglobulin G (HAV-IgG) blood tests should be performed. These should be repeated in one to two weeks if taken within ten days of symptom onset.
- Positive HAV-IgM and positive HAV-IgG suggests acute hepatitis A infection.
- Negative HAV-IgM and positive HAV-IgG suggests past hepatitis A infection or immunity.
- A high IgG reactivity and a moderate level of IgM suggests recent infection rather than acute infection.
- Liver function tests
- Typically shows significantly raised alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels.
- Bilirubin may be elevated, as well as pro-thrombin time.
- Alkaline phosphatase may be elevated but generally less than 2 times upper limit of normal.
Public Health England (PHE) define possible cases of hepatitis A using a case definition, defined as:
- A person presenting with acute illness with onset of suggestive features and jaundice; or
- A person presenting with acute illness with onset of suggestive features and raised AST levels.
Probable and confirmed cases are then defined by PHE using this case definition as in the table below:
|Probable case||Confirmed case|
|Meets case definition (above) and has had contact with a confirmed hepatitis A case||Meets case definition and has HAV-IgM and HAV-IgG antibodies|
|Meets case definition and has HAV-IgM antibodies||Has hepatitis A RNA (HAV-RNA) detected regardless of clinical features|
|Asymptomatic and no recent immunisation but has anti HAV-IgM and has had contact with confirmed hepatitis A case|
- Generally symptom management is all that is required. Current NICE CKS guidance advises a patient should:
- Rest and stay hydrated.
- Use pain relief as required, with dose adjustment if liver impairment.
- Use anti-emetics as required, including metoclopramide or cyclizine unless impaired liver function.
- For itch, use simple measure such as loose clothing and avoiding hot baths and showers and chlorphenamine if required unless impaired liver function.
- Avoid alcohol.
- Ensure good personal hygiene practices and avoid food preparation, and sexual intercourse for 7 days after symptom onset.
- Patients should avoid work or school for 7 days after symptom onset.
- Patients should be followed-up every 1-2 weeks, and liver function tests repeated until amino-transferase levels are within normal levels.
For those who have been in contact with someone with known hepatitis A infection, the local health protection unit should be contacted for advice on further management including vaccination.
- Rarely (15%) of patients may have a relapsing course of illness lasting several months.
- Very rare complications (0.4%) include fulminant liver failure and other rare complications. Other rare complications include:
- Acalculous cholecystitis
- Aplastic anaemia
- Post-viral encephalitis
- Reactive arthritis.