Haemolytic anaemia





Classification

Hereditary haemolytic anaemias can be subdivided into membrane, metabolism or haemoglobin defects

Hereditary causes


Acquired haemolytic anaemias can be subdivided into immune and non-immune causes

Acquired: immune causes
  • autoimmune: warm/cold antibody type
  • alloimmune: transfusion reaction, haemolytic disease newborn
  • drug: methyldopa, penicillin

Acquired: non-immune causes
  • microangiopathic haemolytic anaemia (MAHA): TTP/HUS, DIC, malignancy, pre-eclampsia
  • prosthetic cardiac valves
  • paroxysmal nocturnal haemoglobinuria
  • infections: malaria
  • drug: dapsone

Clinical features