statMed.org is designed to help students of medicine to learn about differential diagnosis.
It is NOT a clinical decision support tool and should NOT be used to guide decisions about clinical practice.
The website should not be used by people who are not studying medicine. If you are not studying medicine please leave the website. statMed.org is for medical educational purposes only and it is not intended to constitute professional medical advice, diagnosis or treatment.
It is NOT a symptom checker.
If you are concerned about a medical problem you should immediately seek medical assistance from a doctor.
statMed.org and it's affiliates, officers and employees shall not be held liable in anyway responsible for any direct or indirect consquences resulting from the use of the website.
Please enter at least one feature (symptom, sign or investigation result) before performing the calculation.
For example, if chest pain and low oxygen saturations were present, but haemoptysis was absent, the features section should look as follows:
To add a feature that is present, start typing and then click the green arrow.
To add the absence of a feature (i.e. a 'negative' finding), start typing then click the red cross.
If you want to remove a feature from the list simply click the grey cross in the box to the right of the feature.
Cryptogenic organizing pneumonia (COP) is a diffuse interstitial lung disease that affects the distal bronchioles, respiratory bronchioles, alveolar ducts and alveolar walls. It affects around 2 people per 100,000. The aetiology is unknown.
Incidence: 2.00 cases per 100,000 person-years
Peak incidence: 50-60 years
Sex ratio: 1:1
Males and females are equally affected and tend to present in the 5th or 6th decade of life and is not associated with smoking. Patients typically present with a cough, shortness of breath, fever and malaise. Symptoms can be present for weeks or months. There is often a history of non-response to antibiotics. Haemoptysis is rare. Clinical examination is often normal but inspiratory crackles can be heard. Wheeze and clubbing are rare.
Bloods show a leukocytosis and an elevated ESR and CRP. Imaging typically shows bilateral patchy or diffuse consolidative or ground glass opacities. Lung function tests are most commonly restrictive but can be obstructive or normal. The transfer factor is reduced.
Treatment is watch and wait if mild or high dose oral steroids if severe.