Introduction
Azathioprine is metabolised to the active compound mercaptopurine, a purine analogue that inhibits purine synthesis. A thiopurine methyltransferase (TPMT) test may be needed to look for individuals prone to azathioprine toxicity.
Adverse effects
Adverse effects include
- Bone marrow depression
- Nausea/vomiting
- Pancreatitis
- Increased risk of non-melanoma skin cancer
Contraindications
A significant interaction may occur with allopurinol and hence lower doses of azathioprine should be used.