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Please enter at least one feature (symptom, sign or investigation result) before performing the calculation.
For example, if chest pain and low oxygen saturations were present, but haemoptysis was absent, the features section should look as follows:
To add a feature that is present, start typing and then click the green arrow.
To add the absence of a feature (i.e. a 'negative' finding), start typing then click the red cross.
If you want to remove a feature from the list simply click the grey cross in the box to the right of the feature.
Aminoglycosides are a type of antibiotic, of which gentamicin is the most widely used. They are poorly lipid soluble and are therefore given parentally (e.g. for infective endocarditis) or topically (e.g. for otitis externa).
Mechanism of action
Aminoglycosides inhibit protein synthesis by disturbing peptide elongation at the 30S ribosomal subunit
Ototoxicity: irreversible, due to auditory or vestibular nerve damage
Nephrotoxicity: accumulates in renal failure, lower doses and more frequent monitoring is required
Due to the significant ototoxic and nephrotoxic potential of gentamicin it is important to monitor plasma concentrations
Both peak (1 hour after administration) and trough levels (just before the next dose) are measured
If the trough (pre-dose) level is high the interval between the doses should be increased
If the peak (post-dose) level is high the dose should be decreased