Introduction

Acute interstitial nephritis accounts for 25% of drug-induced acute kidney injury.

Epidemiology

  • Incidence: 5.00 cases per 100,000 person-years
  • Peak incidence: 60-70 years
  • Sex ratio: more common in males 2:1
<1 1-5 6+ 16+ 30+ 40+ 50+ 60+ 70+ 80+

Aetiology

Causes
  • idiopathic
  • drugs: penicillin, rifampicin, NSAIDs, allopurinol, furosemide
  • infection: Hanta virus , staphylococci

Clinical features

Features

Investigations

Investigations
  • sterile pyuria
  • white cell casts

Complications

Tubulointerstitial nephritis with uveitis

Tubulointerstitial nephritis with uveitis (TINU) usually occurs in young females. Symptoms include fever, weight loss and painful, red eyes. Urinalysis is positive for leukocytes and protein.