Introduction

Acute fatty liver of pregnancy is rare complication which may occur in the third trimester or the period immediately following delivery.

Epidemiology

  • Incidence: 0.30 cases per 100,000 person-years
  • Peak incidence: 30-40 years
<1 1-5 6+ 16+ 30+ 40+ 50+ 60+ 70+ 80+

Clinical features

Features

Investigations

Investigations
  • ALT is typically elevated e.g. 500 u/l

Management

Management
  • supportive care
  • once stabilised delivery is the definitive management